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Furthermore, a single peripheral injection of PYY 3-36 resulted in induction of expression of the immediateearly gene c- fos (a marker of neuronal activation) in the hypothalamic ARC
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This illustrates an increasingly important trend in obesity research: «Rather than asking which single molecule is best, researchers are investigating whether strategically combining mechanisms can produce a broader metabolic effect.» This does not mean every combination will be superior
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